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  Indian J Med Microbiol
 

Table 1: Mechanisms of gene inactivation of the ARF-INK4a locus. These tumor suppressor genes are either underexpressed or overexpressed in human cancers, which will cause dysfunction. ARF overexpression can reflect the p53 inactivation of the tumor, suggesting the role for detection of tumor cells with p53 mutation.

Table 1: Mechanisms of gene inactivation of the <i>ARF-INK4a</i> locus. These tumor suppressor genes are either underexpressed or overexpressed in human cancers, which will cause dysfunction. ARF overexpression can reflect the p53 inactivation of the tumor, suggesting the role for detection of tumor cells with p53 mutation.